Hilary Swank, Sean Lennon, Charlotte Kemp Muhl

Season 6 - Episode 1

Gabrielle Union, Nick Cave

Season 6 - Episode 2

Usher, Joan Jett

Season 6 - Episode 3

Dr. Phil McGraw, Kelsea Ballerini

Season 6 - Episode 4

Rainn Wilson, Anthony Ramos

Season 6 - Episode 5

John David Washington, Michael McIntyre, Glass Animals

Season 6 - Episode 6

James welcomes actor John David Washington, comedian Michael McIntyre, and a musical performance by Glass Animals.

Neil Patrick Harris, Ziggy Marley, Ben Harper

Season 6 - Episode 7

Alicia Keys

Season 6 - Episode 8

Ken Jeong, Alicia Keys, Khalid

Season 6 - Episode 9

Sharon Stone, Alicia Keys

Season 6 - Episode 10

Jason Schwartzman, Alicia Keys

Season 6 - Episode 11

Jeff Daniels, Summer Walker

Season 6 - Episode 12

Andrew Rannells, Brittany Howard

Season 6 - Episode 13

Hillary Clinton

Season 6 - Episode 14

Tyra Banks, Evan Rachel Wood

Season 6 - Episode 15

Seth MacFarlane, Jaded Hearts Club

Season 6 - Episode 16

Whoopi Goldberg, Bishop Briggs

Season 6 - Episode 17

Whoopi Goldberg and Bishop Briggs are spotlighted.

Gloria Steinem, Sally Hawkins, Craig Roberts, Conan Gray

Season 6 - Episode 18

Armie Hammer, Surfaces

Season 6 - Episode 19

Bill Gates, The Head and the Heart

Season 6 - Episode 20

Josh Gad, The Score, AWOLNATION

Season 6 - Episode 21

Jeremy Strong, SuperM

Season 6 - Episode 22

Aaron Sorkin, The Shins

Season 6 - Episode 23

Billy Porter, David Byrne, Kane Brown

Season 6 - Episode 24

Chelsea Handler, CL

Season 6 - Episode 25

Vin Diesel, Jack Peñate

Season 6 - Episode 26

Pete Buttigieg, Travis

Season 6 - Episode 27

Henry Winkler, The Kills

Season 6 - Episode 28

Tig Notaro, Christine and the Queens

Season 6 - Episode 29

Dr. Michael Eric Dyson, Henry Golding, Ella Mai

Season 6 - Episode 30

David Oyelowo, Sam Smith

Season 6 - Episode 31

Thomas Middleditch, Black Pumas

Season 6 - Episode 32

Max Greenfield, Ashe, Niall Horan

Season 6 - Episode 33

Cory Booker, Jack Harlow

Season 6 - Episode 34

Will Arnett, Maria Bakalova

Season 6 - Episode 35

Melissa McCarthy, Bobby Cannavale, FITZ

Season 6 - Episode 36

Alison Brie, Yuval Noah Harari

Season 6 - Episode 37

Marc Maron, Royal Blood

Season 6 - Episode 38

Michael J. Fox, BTS

Season 6 - Episode 39

Goldie Hawn, Kurt Russell, BTS

Season 6 - Episode 40

Chris Rock, Rauw Alejandro, J Balvin

Season 6 - Episode 41

John Lithgow, Gary Barlow

Season 6 - Episode 42

Riz Ahmed, Bad Bunny

Season 6 - Episode 43

Actor Riz Ahmed (Sound of Metal); Bad Bunny performs.

Bryan Cranston, Rufus Wainwright

Season 6 - Episode 44

Kevin Bacon, Jamie Oliver

Season 6 - Episode 45

Matthew McConaughey, Shawn Mendes

Season 6 - Episode 46

Meryl Streep, Billy Eichner

Season 6 - Episode 47

Jamie Dornan, Dr. Michael Eric Dyson

Season 6 - Episode 48

Andrew Rannells, Megan Thee Stallion

Season 6 - Episode 49

Kyle Chandler, Meghan Trainor

Season 6 - Episode 50

Keegan-Michael Key, Roddy Ricch

Season 6 - Episode 51

Nicole Kidman, Kerry Washington, Phoebe Bridgers

Season 6 - Episode 52

Gal Gadot, Smith & Burrows

Season 6 - Episode 53

Rosario Dawson, Ingrid Andress

Season 6 - Episode 54

James Marsden, Tim Minchin

Season 6 - Episode 55

Jim Gaffigan, Seventeen

Season 6 - Episode 56

Michael Sheen, Jo Ellen Pellman

Season 6 - Episode 57

Rob Lowe, Zoe Wees

Season 6 - Episode 58

Liam Neeson, Annaleigh Ashford, Pillow Queens

Season 6 - Episode 59

Paul Bettany, Lennie James

Season 6 - Episode 60

Michael Moore, Andie MacDowell, Why Don't We

Season 6 - Episode 61

Anthony Mackie, Machine Gun Kelly

Season 6 - Episode 62

Dakota Johnson, AJR

Season 6 - Episode 63

Regina King, Amanda Gorman

Season 6 - Episode 64

Rob Gronkowski, Joe Montana, Stephen Curry

Season 6 - Episode 65

Halsey, Penn & Teller

Season 6 - Episode 66

Jared Leto, Jacob Collier

Season 6 - Episode 67

Adam Devine, BLACKPINK

Season 6 - Episode 68

Carey Mulligan, Jhene Aiko

Season 6 - Episode 69

Viggo Mortensen, Quinn XCII, Chelsea Cutler

Season 6 - Episode 70

Naomi Watts, FINNEAS

Season 6 - Episode 71

Kal Penn, Josh Groban

Season 6 - Episode 72

Dan Stevens, Michael Kiwanuka

Season 6 - Episode 73

Salma Hayek, Owen Wilson, The Weeknd

Season 6 - Episode 74

Rob Gronkowski, Elle Fanning, Sabrina Carpenter

Season 6 - Episode 75

Noah Centineo, Madison Cunningham

Season 6 - Episode 76

Mila Kunis, Robin Thicke

Season 6 - Episode 77

Kristen Wiig, Annie Mumolo, Masego and Don Toliver

Season 6 - Episode 78

Kristen Wiig; Annie Mumolo; musical performance by Masego feat. Don Toliver.

Drew Barrymore, Storm Reid

Season 6 - Episode 79

Stanley Tucci, Pentatonix

Season 6 - Episode 80

Jodie Foster, Prince Harry, Holly Humberstone

Season 6 - Episode 81

Jamie Dornan, Kelly Marie Tran

Season 6 - Episode 82

Tom Brady, Stacey Abrams, JP Saxe, Maren Morris

Season 6 - Episode 83

Ben Schwartz, Foo Fighters

Season 6 - Episode 84

Daisy Ridley, Caroline Polachek

Season 6 - Episode 85

Daisy Ridley; musical performance by Caroline Polachek.

Andra Day, SG Lewis, Nile Rodgers

Season 6 - Episode 86

Tracy Morgan, Kings of Leon

Season 6 - Episode 87

Trevor Noah, Grouplove

Season 6 - Episode 88

Eddie Murphy, Tiana Major9

Season 6 - Episode 89

Venus Williams, Picture This

Season 6 - Episode 90

Chuck Schumer, Sam Smith

Season 6 - Episode 91

Allison Janney, Inhaler

Season 6 - Episode 92

Benedict Cumberbatch, Justin Bieber

Season 6 - Episode 93

David Tennant, Joy Downer

Season 6 - Episode 94

Bear Grylls, Middle Kids

Season 6 - Episode 95

Minnie Driver, Benny Blanco, Gracie Abrams

Season 6 - Episode 96

Chrissy Teigen, NEEDTOBREATHE

Season 6 - Episode 97

Bob Odenkirk, The Fratellis

Season 6 - Episode 98

Neil deGrasse Tyson, Arlo Parks

Season 6 - Episode 99

Kenan Thompson, Julien Baker

Season 6 - Episode 100

Jeffrey Dean Morgan, London Grammar

Season 6 - Episode 101

Rainn Wilson, Tom Odell

Season 6 - Episode 102

Vanessa Kirby, Darren Criss

Season 6 - Episode 103

Keith Urban, Jon Batiste

Season 6 - Episode 104

Forest Whitaker, Kane Brown

Season 6 - Episode 105

Ron Funches, Karol G

Season 6 - Episode 106

Angela Bassett, KSI, Yungblud, Polo G

Season 6 - Episode 107

Cher, Jackson Wang

Season 6 - Episode 108

Dominic Cooper, Static & Ben El, Black Eyed Peas

Season 6 - Episode 109

Pete Buttigieg, Jordan McGraw

Season 6 - Episode 110

Zion Williamson, Years & Years

Season 6 - Episode 111

Jason Schwartzman, Gabby Barrett

Season 6 - Episode 112

Brian Tyree Henry, Tom Grennan

Season 6 - Episode 113

Tiffany Haddish, Dominic Fike

Season 6 - Episode 114

Ellen DeGeneres, Wolf Alice

Season 6 - Episode 115

Billy Porter, Brett Gelman

Season 6 - Episode 116

Max Greenfield, Alec Benjamin

Season 6 - Episode 117

David Oyelowo, Maisie Peters

Season 6 - Episode 118

Martin Freeman, Rag'n'Bone Man

Season 6 - Episode 119

Sharon Stone, Matthew Rhys

Season 6 - Episode 120

Ben Platt

Season 6 - Episode 121

Barack Obama, Kelly Rowland

Season 6 - Episode 122

Regina Hall, Moby

Season 6 - Episode 123

Eric Bana, Pete Holmes

Season 6 - Episode 124

Hank Azaria, Sara Bareilles

Season 6 - Episode 125

Don Cheadle, Rafe Spall

Season 6 - Episode 126

Andrew Rannells, All Time Low

Season 6 - Episode 127

Jonas Brothers, Leif Vollebekk

Season 6 - Episode 128

Emily Blunt, Elle King

Season 6 - Episode 129

Julianne Moore, Rufus Wainwright

Season 6 - Episode 130

James welcomes actress Julianne Moore and a musical performance by Rufus Wainwright.

Chelsea Handler, The Wallflowers

Season 6 - Episode 131

James welcomes actress Chelsea Handler and a musical performance by The Wallflowers.

Lisa Kudrow, Clea Duvall, Rostam

Season 6 - Episode 132

James welcomes actress Lisa Kudrow, actress Clea DuVall, and a musical performance by Rostam.

Desus & Mero, Mother Mother

Season 6 - Episode 133

James welcomes the podcast hosts of Desus & Mero and a musical performance by Mother Mother.

Hugh Grant, Mike Colter, Tomorrow X Together

Season 6 - Episode 134

James welcomes actor Hugh Grant, actor Mike Colter, and a musical performance by Tomorrow X Together.

Gavin Newsom, Migos

Season 6 - Episode 135

James welcomes governor Gavin Newsom and rap group Migos.

Margot Robbie, Rose Byrne, Polo G

Season 6 - Episode 136

James welcomes actress Margot Robbie, actress Rose Byrne, and a musical performance by Polo G.

Will Arnett, Lord Huron

Season 6 - Episode 137

James welcomes actor Will Arnett and a musical performance by Lord Huron.

Helen Hunt, Black Pumas

Season 6 - Episode 138

James welcomes actress Helen Hunt and a musical performance by Black Pumas.

Elizabeth Olsen, Edgar Wright

Season 6 - Episode 139

James welcomes actress Elizabeth Olsen and film director Edgar Wright.

Josh Gad, Chloe Moriondo

Season 6 - Episode 140

James welcomes actor Josh Gad and a musical performance by Chloe Moriondo.

Liam Neeson, Anthony Ramos

Season 6 - Episode 141

James welcomes actor Liam Neeson and a musical performance by Anthony Ramos.

Ed Sheeran

Season 6 - Episode 142

James welcomes a talk and a musical performance by Ed Sheeran.

Steve Buscemi, Ed Sheeran

Season 6 - Episode 143

James welcomes actor Steve Buscemi and a musical performance by Ed Sheeran.

Heidi Klum, Ed Sheeran

Season 6 - Episode 144

James welcomes television host Heidi Klum and a musical performance by Ed Sheeran.

Chris Pratt, Ed Sheeran

Season 6 - Episode 145

James welcomes actor Chris Pratt and a musical performance by Ed Sheeran.

Jason Momoa, Lorde

Season 6 - Episode 146

James welcomes actor Jason Momoa and a musical performance by Lorde.

Lorde

Season 6 - Episode 147

James welcomes a talk and musical performance by Lorde.

Bradley Whitford, Lorde

Season 6 - Episode 148

James welcomes actor Bradley Whitford and a musical performance by Lorde.

Terry Crews, Lorde

Season 6 - Episode 149

James welcomes actor Terry Crews and a musical performance by Lorde.

Camila Cabello, Rufus Du Sol

Season 6 - Episode 150

James welcomes singer Camila Cabello, and a musical performance by Rufus Du Sol.

Lil Rel Howery, Billie Piper

Season 6 - Episode 151

James welcomes actor Lil Rel Howery and actress Billie Piper.

Clive Owen, James Arthur

Season 6 - Episode 152

James welcomes actor Clive Owen, and a musical performance by James Arthur.

David Duchovny, The Killers

Season 6 - Episode 153

James welcomes actor David Duchovny and a musical performance by The Killers.