Luke Wilson, Julie Chen, Lee Brice

Season 22 - Episode 1

Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers

Season 22 - Episode 2

Steve Buscemi, Indy Car Season Champ, Alt-J

Season 22 - Episode 3

Tina Fey, Moody McCarthy, Kevin Drew

Season 22 - Episode 4

Bill Maher, Henrik Lundqvist, Spoon

Season 22 - Episode 5

Michael Strahan, Richard Branson, Interpol

Season 22 - Episode 6

Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson

Season 22 - Episode 7

Jason Bateman, Billy Eichner, Ryan Adams

Season 22 - Episode 8

Mindy Kaling, Jake Johannsen, Maddie & Tae

Season 22 - Episode 9

Mark Harmon, "Jungle" Jack Hanna

Season 22 - Episode 10

Denzel Washington, Lenny Kravitz

Season 22 - Episode 11

Kelly Ripa, Jim Gaffigan, Paloma Faith

Season 22 - Episode 12

Jerry Seinfeld, Michael Jackson ONE

Season 22 - Episode 13

Ted Danson, Andrew Norelli

Season 22 - Episode 14

Neil Patrick Harris, Jamie Oliver, Aretha Franklin

Season 22 - Episode 15

John Oliver, Maggie Q, Bleachers

Season 22 - Episode 16

Bill O'Reilly, Cristin Milioti

Season 22 - Episode 17

Johnny Galecki, Andre Benjamin, Delta Spirit

Season 22 - Episode 18

Mariska Hargitay, Simon Amstell, Kandace Springs

Season 22 - Episode 19

Aziz Ansari, Tom Dreesen

Season 22 - Episode 20

Robert Downey Jr., Sarah Paulson, Lizzo

Season 22 - Episode 21

Anderson Cooper, Gina Rodriguez, Hatsune Miku

Season 22 - Episode 22

Robert Duvall, Elle Fanning, Rival Sons

Season 22 - Episode 23

Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley

Season 22 - Episode 24

TV host Chelsea Handler; comics Keegan-Michael Key and Jordan Peele; Angaleena Presley performs.

Russell Brand, Dave Grohl, Foo Fighters

Season 22 - Episode 25

Michael Keaton, Foo Fighters

Season 22 - Episode 26

Bill Murray, Foo Fighters

Season 22 - Episode 27

Tom Selleck, Jenny Slate, Foo Fighters

Season 22 - Episode 28

Jessica Chastain, Lenny Marcus, Foo Fighters

Season 22 - Episode 29

Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis

Season 22 - Episode 30

Taylor Swift, Tom Mison

Season 22 - Episode 31

Jim Carrey, David Tennant

Season 22 - Episode 32

Brian Williams, Perfume Genius

Season 22 - Episode 33

Keith Olbermann, Brian Regan, Run the Jewels

Season 22 - Episode 34

Martin Short, Father John Misty

Season 22 - Episode 35

Jennifer Lopez, Rob Riggle, Kimbra

Season 22 - Episode 36

Whoopi Goldberg, Jimmy Page, Mapei

Season 22 - Episode 37

Amy Schumer, Jeff Caldwell

Season 22 - Episode 38

Katie Holmes, Alex Zanardi

Season 22 - Episode 39

Steve Carell, Martha Stewart, OK Go

Season 22 - Episode 40

Jennifer Lawrence, Boris Johnson

Season 22 - Episode 41

Jon Stewart, Shawn Mendes

Season 22 - Episode 42

Kristin Chenoweth; Chris Young

Season 22 - Episode 43

Actress Kristin Chenoweth; Chris Young performs.

Jason Sudeikis, Allison Janney, Damien Rice

Season 22 - Episode 44

Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger

Season 22 - Episode 45

Regis Philbin, Hundred Waters

Season 22 - Episode 46

Edward Norton, Jessye Norman

Season 22 - Episode 47

Norman Lear, TV on the Radio

Season 22 - Episode 48

Seth Rogen, Amy Sedaris

Season 22 - Episode 49

Emily Blunt, Adam Resnick, Wu-Tang Clan

Season 22 - Episode 50

Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz

Season 22 - Episode 51

Joaquin Phoenix, Cristela Alonzo, Al Green

Season 22 - Episode 52

Ben Stiller, Olivia Munn, LaLa Brooks

Season 22 - Episode 53

Meryl Streep, Rebel Wilson, J. Cole

Season 22 - Episode 54

Chris Rock, Sting

Season 22 - Episode 55

Jamie Foxx, Robert Klein, Dan Penn

Season 22 - Episode 56

Emma Stone Top, Marcus Mariota, Bob Seger

Season 22 - Episode 57

New Holiday Toys, Anna Kendrick, Charli XCX

Season 22 - Episode 58

Tom Brokaw, Will Nelson & Billy Joe Shaver

Season 22 - Episode 59

Rosie O’Donnel,l Jeff Altman

Season 22 - Episode 60

Jay Thomas, Josh Brolin, Darlene Love

Season 22 - Episode 61

The final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the mea...

Kathy Griffin, David Oyelowo, Lera Lynn

Season 22 - Episode 62

Ethan Hawke, Allison Williams, Parquet Courts

Season 22 - Episode 63

Julianne Moore, Catfish & the Bottlemen

Season 22 - Episode 64

Donald Trump, Chelsea Peretti, Foxygen

Season 22 - Episode 65

Michael Somerville, Nicole Atkins

Season 22 - Episode 66

Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones

Season 22 - Episode 67

Anderson Cooper, Shovels & Rope

Season 22 - Episode 68

Amanda Peet, Ryn Weaver

Season 22 - Episode 69

Larry David, Dan Patrick, Sleater-Kinney

Season 22 - Episode 70

Urban Meyer, Johnny Beehner, Ella Henderson

Season 22 - Episode 71

Louis CK, Nicolle Wallace, the Lone Bellow

Season 22 - Episode 72

Andrew Luck, Oscar Isaac, Drenge

Season 22 - Episode 73

Viola Davis, Ben Schwartz, Marty Stuart

Season 22 - Episode 74

John Oliver, Mayim Bialik, Death Cab for Cutie

Season 22 - Episode 75

Aziz Ansari, Brian Kiley, Ben Howard

Season 22 - Episode 76

Jack Hanna, Sharon Jones and the Dap-Kings

Season 22 - Episode 77

Dr. Phil McGraw, Robin Tunney, Diana Krall

Season 22 - Episode 78

Ryan Reynolds, Dierks Bentley

Season 22 - Episode 79

Martin Short, Bettye Lavette

Season 22 - Episode 80

Sienna Miller, Andy Kindler, Bob Mould

Season 22 - Episode 81

Steve Carell, Dr. Cornel West

Season 22 - Episode 82

Courtney Love, Chris Elliott, Rhiannon Giddens

Season 22 - Episode 83

Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear

Season 22 - Episode 84

Tom Hanks, Sturgill Simpson

Season 22 - Episode 85

Bill Hader, Pat McGann, Shakey Graves

Season 22 - Episode 86

Matthew Perry, Adam Scott, Kishi Bashi

Season 22 - Episode 87

Dakota Johnson, David Tochinskiy, Twin Shadow

Season 22 - Episode 88

Will Smith, Grizfolk

Season 22 - Episode 89

Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko

Season 22 - Episode 90

Kid Scientists, Sean Hayes, Judah & the Lion

Season 22 - Episode 91

Helen Mirren, the 2015 Daytona 500 winner, Steve Earle

Season 22 - Episode 92

Matthew Broderick, Ellie Kemper, JD McPherson

Season 22 - Episode 93

Julianna Margulies, Eric Ripert, Glass Animals

Season 22 - Episode 94

Kevin Spacey, Lily James, Alabama Shakes

Season 22 - Episode 95

Patricia Arquette, Will Butler

Season 22 - Episode 96

Kelsey Grammer, Stevie Wonder

Season 22 - Episode 97

Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew

Season 22 - Episode 98

Kevin Bacon, Jimmie Walker, Airborne Toxic Event

Season 22 - Episode 99

Shailene Woodley, Dr. Cornel West, Matthew E. White

Season 22 - Episode 100

Will Ferrell, Glen Hansard

Season 22 - Episode 101

Norm MacDonald, Theo James

Season 22 - Episode 102

Ben Stiller, Tove Lo

Season 22 - Episode 103

Bill O'Reilly, Aubrey Plaza

Season 22 - Episode 104

James Franco, Jake Johannsen, Action Bronson

Season 22 - Episode 105

Neil Patrick Harris, Charlie Cox, the Suffers

Season 22 - Episode 106

David Duchovny, Josh Gad, Houndmouth

Season 22 - Episode 107

Sen. Al Franken, Billy Eichner, David Sanborn

Season 22 - Episode 108

Kelly Ripa, Aasif Mandvi, Fat White Family

Season 22 - Episode 109

Mike Myers, Nick Griffin, Banks

Season 22 - Episode 110

Sarah Jessica Parker, Julie Chen, Asleep at the Wheel

Season 22 - Episode 111

Billy Crystal, Chris Russo, Chris Stapleton

Season 22 - Episode 112

Michael J. Fox, Iron & Wine, Ben Bridwell

Season 22 - Episode 113

Kevin James, Tom Dreesen, Tracy Chapman

Season 22 - Episode 114

Alec Baldwin, John Mayer

Season 22 - Episode 115

John Travolta, Amy Schumer, the Waterboys

Season 22 - Episode 116

Piedmont Bird Callers, Paul Rudd

Season 22 - Episode 117

Bruce Willis, Dawes

Season 22 - Episode 118

Robert Downey Jr., Chris Russo, Elvis Costello

Season 22 - Episode 119

Jerry Seinfeld, Jason Isbell & Amanda Shires

Season 22 - Episode 120

Scarlett Johansson, John Mellencamp, Todd Rundgren

Season 22 - Episode 121

Michael Keaton, Future Islands

Season 22 - Episode 122

Jack Hanna, John Popper

Season 22 - Episode 123

First Lady Michelle Obama Hootie and the Blowfish

Season 22 - Episode 124

Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor

Season 22 - Episode 125

President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile

Season 22 - Episode 126

Reese Witherspoon, Nathan Lane, Mumford & Sons

Season 22 - Episode 127

Martin Short, Norah Jones

Season 22 - Episode 128

Tina Fey, First Aid Kit

Season 22 - Episode 129

Ray Romano, Brian Regan, Dave Matthews Band

Season 22 - Episode 130

Howard Stern, Don Rickles

Season 22 - Episode 131

Bill Clinton, Adam Sandler

Season 22 - Episode 132

Julia Roberts, Paul Shaffer, Ryan Adams

Season 22 - Episode 133

Al Pacino, George Clooney, Tom Waits

Season 22 - Episode 134

Oprah Winfrey, Norm Macdonald

Season 22 - Episode 135

Tom Hanks, Eddie Vedder

Season 22 - Episode 136

Bill Murray, Bob Dylan

Season 22 - Episode 137

The Final Late Show with David Letterman

Season 22 - Episode 138

6,028th broadcast

Episode 149

Season 22 - Episode 149

The final episode includes surprises, memorable highlights and the last Top Ten List.