Paul Giamatti

Season 16 - Episode 1

The media calls Barack Obama the "comeback kid," and Paul Giamatti says "rapscallion.

Sen. Kirsten Gillibrand

Season 16 - Episode 2

Republicans focus on 2010 issues, and Kirsten Gillibrand wants to reform the Senate filibuster rules.

Jimmy Wales

Season 16 - Episode 3

John McCain gets cranky, and Jimmy Wales imagines Wikipedia's relevance in 500 years.

Patton Oswalt

Season 16 - Episode 4

Facebook refuses to disclose its financial results, and Patton Oswalt uses a prisoner ghostwriter.

Denis Leary

Season 16 - Episode 5

John Oliver reports on the Arizona shootings in his PJs, and Denis Leary discusses "Suck on This Year.

Colin Firth

Season 16 - Episode 6

John Oliver celebrates Verizon's iPhone announcement, and Colin Firth talks about "The King's Speech.

Tim Pawlenty

Season 16 - Episode 7

Members of Congress introduce gun legislation, and Tim Pawlenty defends Republican rhetoric.

Ron Howard

Season 16 - Episode 8

John Hodgman makes NASCAR more exciting, and Ron Howard shares his enthusiasm for show business.

Peter Bergen

Season 16 - Episode 9

Michael Steele steps down as RNC chairman, and Peter Bergen talks about progress in Afghanistan.

Neil deGrasse Tyson

Season 16 - Episode 10

Jon promises Sarah Palin a classy conversation and reveals his love for Neil deGrasse Tyson.

Paul Clemens

Season 16 - Episode 11

Glenn Beck appears on the "Today" show, and Paul Clemens discusses blue-collar decline.

Kambiz Hosseini & Saman Arbabi

Season 16 - Episode 12

Steve Cohen compares Republicans to Nazis, and Kambiz Hosseini and Saman Arbabi call Jon a prophet.

Anand Giridharadas

Season 16 - Episode 13

Wyatt Cenac dons a parrot suit in Mississippi, and Anand Giridharadas tells Jon the truth.

James Franco

Season 16 - Episode 14

A reporter searches for homeless talent, and Jon composes an ode to James Franco's Oscar nomination.

Jonathan Alter

Season 16 - Episode 15

Michele Bachmann looks off camera, and Jonathan Alter examines Obama's plans for the future.

T. Boone Pickens

Season 16 - Episode 16

Bill O'Reilly defends his Nazi analogies, and T. Boone Pickens wants America on an energy plan.

Bill Gates

Season 16 - Episode 17

Egyptian forces use American tear gas canisters, and Bill Gates works on curing polio.

Michael Steele

Season 16 - Episode 18

Conservatives turn into political hypochondriacs, and Michael Steele must prove his identity.

Matthew Perry

Season 16 - Episode 19

Republicans close the rape loophole, and Matthew Perry talks about his happy friend.

Adm. Michael Mullen

Season 16 - Episode 20

Justin Bieber switches bodies with Jon, and Mike Mullen talks about the crisis in Egypt.

Edward Glaeser

Season 16 - Episode 21

January Jones

Season 16 - Episode 22

Brian Williams

Season 16 - Episode 23

Anchor and Managing Editor, NBC Nightly News. The award-winning journalist and friend-of-the-show stops by.

Ed Gillespie

Season 16 - Episode 24

Lisa Ling

Season 16 - Episode 25

Anderson Cooper

Season 16 - Episode 26

Donald Rumsfeld

Season 16 - Episode 27

Austan Goolsbee

Season 16 - Episode 28

Howard Stern

Season 16 - Episode 29

CNN anchors take viewer requests, and Howard Stern hopes to talk to Charlie Sheen.

Prince Zeid Ra'ad

Season 16 - Episode 30

Prince Zeid Ra'ad Representative, The Hashemite Kingdom of Jordan The U.N. representative of Jordan discusses King Abdullah II's new book, "...

Allison Stanger

Season 16 - Episode 31

Diane Ravitch

Season 16 - Episode 32

Sen. Rand Paul

Season 16 - Episode 33

Brian Christian

Season 16 - Episode 34

Author Brian Christian ('The Most Human Human: What Talking with Computers Teaches Us About What It Means to Be Alive').

Aaron Eckhart

Season 16 - Episode 35

From 'Battle: Los Angeles,' actor Aaron Eckhart.

Trey Parker & Matt Stone

Season 16 - Episode 36

'South Park,' creators Trey Parker and Matt Stone.

Sarah Vowell

Season 16 - Episode 37

Author, "Unfamiliar Fishes." The author discusses her new book about American colonization of Hawaii in the 1800s.

T.J. English

Season 16 - Episode 38

The author of "The Savage City" discusses his new book about murder and corruption in New York City during the 1960s and 70s.

Richard Lewis

Season 16 - Episode 39

Bret Baier

Season 16 - Episode 40

Dr. Mansour O.El-Kikhia

Season 16 - Episode 41

Republicans want to lower the corporate tax rate, and Mansour O. El-Kikhia discusses Libya.

Miguel Nicoleles

Season 16 - Episode 42

Joe Biden works the room at a war speech, and Miguel Nicolelis helps paralyzed people walk again.

Jake Gyllenhaal

Season 16 - Episode 43

Republicans appeal to their narrow base, and Jake Gyllenhaal considers marrying a stranger.

Norm MacDonald

Season 16 - Episode 44

CIA operatives might arm Libyan rebels, and Norm Macdonald wants to blow up his stupid high school.

Billy Crystal

Season 16 - Episode 45

The comedian and actor discusses his role as a vampire in an upcoming Funny Or Die short.

Colin Quinn

Season 16 - Episode 46

The comedian discusses his one-man Broadway show and special on HBO.

Mike Huckabee

Season 16 - Episode 47

The former governor of Arkansas discusses his views on government, families and his latest book.

Jamie Oliver

Season 16 - Episode 48

The chef talks about healthy cooking habits and the upcoming season of his Emmy-winning series.

Foo Fighters

Season 16 - Episode 49

The rock band visits to perform a song from their latest album.

Governor Deval Patrick

Season 16 - Episode 50

The governor of Massachusetts discusses his rise from poverty and what gives him hope for America's future.

Tracy Morgan

Season 16 - Episode 51

The actor and comedian discusses his role in the upcoming animated film.

Ricky Gervais

Season 16 - Episode 52

The comedian talks about his new HBO special with Jerry Seinfeld, Chris Rock and Louis C.K.

Gigi Ibrahim

Season 16 - Episode 53

John Oliver highlights royal wedding coverage, and Gigi Ibrahim talks about the Egyptian uprising.

Elizabeth Warren

Season 16 - Episode 54

Olivia Munn looks into tiger mothering, and Elizabeth Warren wants to protect consumers.

Bernie Sanders

Season 16 - Episode 55

Obama releases his long-form birth certificate, and Bernie Sanders fights for workers' rights.

William Cohan

Season 16 - Episode 56

John Oliver talks to British taxpayers about the wedding, and William Cohan discusses Goldman Sachs.

Philip K. Howard

Season 16 - Episode 57

The U.S. kills Osama bin Laden, and Philip K. Howard explains why the government can't make choices.

Rachel Maddow

Season 16 - Episode 58

A royal wedding simulation reveals the consummation, and Rachel Maddow discusses Bin Laden's death.

David Barton

Season 16 - Episode 59

The White House hides the Bin Laden photo, and David Barton discusses religion in the Constitution.

Joe Meacham

Season 16 - Episode 60

Donald Trump steals the crazy oxygen from Sarah Palin, and Jon Meacham discusses the Civil War.

Keira Knightley

Season 16 - Episode 61

Jason Jones visits the gayest city in America, and Keira Knightley learns about the Santorum.

Will Ferrell

Season 16 - Episode 62

Republicans take credit for Bin Laden's death, and Will Ferrell simulates sex with a baseball bat.

Albert Brooks

Season 16 - Episode 63

Common causes controversy, and Albert Brooks talks about his Kate Middleton obsession.

Kristen Wiig

Season 16 - Episode 64

Newt Gingrich announces his candidacy on Twitter, and Kristen Wiig talks about "Bridesmaids.

Jon Ronson

Season 16 - Episode 65

Osama bin Laden's porn stash is discovered, and Jon Ronson talks about psychopaths.

Annie Jacobsen

Season 16 - Episode 66

Al Madrigal weighs in on immigration reform, and Annie Jacobsen talks about Area 51.

Richard Beeman

Season 16 - Episode 67

Newt Gingrich outrages Republicans, and Richard Beeman discusses religion in government.

Lisa P. Jackson

Season 16 - Episode 68

John Hodgman creates a Bin Laden conspiracy theory, and Lisa P. Jackson addresses EPA criticism.

Jimmy Fallon

Season 16 - Episode 69

Sarah Palin takes a bus tour with her family, and Jimmy Fallon reads a thank you note.

Bill Moyers

Season 16 - Episode 70

Donald Trump eats his pizza with a fork, and Bill Moyers discusses good journalism.

Tim Tebow

Season 16 - Episode 71

Eric Cantor wants to justify tornado relief, and Tim Tebow talks about his missionary parents.

Maziar Bahari

Season 16 - Episode 72

Sarah Palin offers her version of Paul Revere, and Maziar Bahari recounts his Iranian imprisonment.

Fareed Zakaria

Season 16 - Episode 73

John Oliver promises to mock Anthony Weiner, and Fareed Zakaria discusses American labor.

Larry King

Season 16 - Episode 74

Anthony Weiner apologizes to Bill Clinton, and Larry King prepares for his European stand-up tour.

Howard Wasdin

Season 16 - Episode 75

Jon spins the penis wheel, and Howard Wasdin talks about SEAL Team Six.

Alex Prud'homme

Season 16 - Episode 76

Nancy Pelosi calls on Anthony Weiner to resign, and Alex Prud'homme discusses water pollution.

J.J. Abrams

Season 16 - Episode 77

Republican hopefuls gather for their second debate, and J.J. Abrams talks about writing for TV.

Trey Parker & Matt Stone

Season 16 - Episode 78

Barack Obama visits Puerto Rico, and Trey Parker and Matt Stone become the Broadway establishment.

Ray Nagin

Season 16 - Episode 79

Sam Bee reports on the smoking ban in NYC parks, and Ray Nagin discusses Hurricane Katrina.

Cameron Diaz

Season 16 - Episode 80

PolitiFact checks Fox News for false statements, and Cameron Diaz removes Jon's stitches.

Mitchell Zuckoff

Season 16 - Episode 81

Greece protests proposed austerity measures, and Mitchell Zuckoff recounts an unlikely WWII rescue.

Bruce Headlam

Season 16 - Episode 82

John Hodgman battles hackers on their own turf, and Bruce Headlam discusses "Page One.

Jennifer Aniston

Season 16 - Episode 83

New York legalizes gay marriage, and Jennifer Aniston talks about her movie, "Horrible Bosses.

Louis C.K.

Season 16 - Episode 84

Rod Blagojevich has much to look forward to in prison, and Louis C.K. deconstructs fart jokes.

Tom Hanks

Season 16 - Episode 85

Democrats and Republicans can't agree on the debt ceiling, and Tom Hanks discusses his movie "Larry Crowne.

Bill Kristol

Season 16 - Episode 86

Mark Halperin calls Barack Obama a dick, and Bill Kristol discusses American war strategy in Afghanistan.

Denis Leary

Season 16 - Episode 87

Aasif Mandvi finds out why America's birds are dying, and Denis Leary talks about potato Vodka.

Kid Rock

Season 16 - Episode 88

China might repossess America if Republicans and Democrats don't come to an agreement over the debt crisis, and Kid Rock is a responsible pa...

Matthew Richardson

Season 16 - Episode 89

Jerry Seinfeld helps Jon repress his urge to make gay jokes about Marcus Bachmann, and Matthew Richardson reveals his plan to solve America'...

Sgt. 1st Class Leroy Petry

Season 16 - Episode 90

The ongoing debt ceiling negotiations get heated, and Leroy Petry demonstrates his robotic hand.

Daniel Radcliffe

Season 16 - Episode 91

Barack Obama breaks out his I-mean-business podium and sets a deadline to solve the debt ceiling crisis, and Daniel Radcliffe talks about th...

Pervez Musharraf

Season 16 - Episode 92

The Murdoch scandal turns ugly, and Pervez Musharraf enjoys a beverage and converses about Pakistan.

Steve Carell

Season 16 - Episode 93

Rupert Murdoch throws his employees under the bus, his wife pummels a pie-wielding idiot, and Steve Carell loves his papa bear.

Scott Miller

Season 16 - Episode 94

A battle for survival rages among GOP presidential candidates, Allen West doesn't hate women, and Scott Miller discusses William McKinley's ...

Neil Patrick Harris

Season 16 - Episode 95

Wyatt Cenac proves his commitment to weather reporting, Samantha Bee and Jason Jones interview gay newlyweds, and Neil Patrick Harris talks ...

Juan Williams

Season 16 - Episode 96

Barack Obama urges Americans to call their members of Congress about the debt crisis, and Juan Williams discusses the assault on honest deba...

Rachel Weisz

Season 16 - Episode 97

Conservatives in America live a lonely life of persecution, and Rachel Weisz discusses filming "The Whistleblower" in Romania.

Peter Tomsen

Season 16 - Episode 98

Congressional Republicans try to rev support for John Boehner's debt ceiling plan with a clip from "The Town," and Peter Tomsen discusses th...

Freida Pinto

Season 16 - Episode 99

Congress reaches a budget deal that Tea Partiers don't like, Jon salutes the troops he met in Afghanistan, and Freida Pinto talks apes.

Jason Bateman

Season 16 - Episode 100

Joe Biden charges his Secret Servicemen rent, Aasif Mandvi explores the effects of wind farming on Florida's ducks, and Jason Bateman talks ...

Austan Goolsbee

Season 16 - Episode 101

A congressional super committee answers America's prayers, Wyatt Cenac interprets public sentiment, and Austan Goolsbee finds it hard to wor...

Dick Durbin

Season 16 - Episode 102

Jon gives Barack Obama a birthday present, Jason Jones survives a vasectomy, and Senator Dick Durbin understands America's disappointment in...

Mark Adams

Season 16 - Episode 103

America's credit gets downgraded, John Oliver tells the single greatest story he's ever heard, and Mark Adams turns right at Machu Picchu.

Jay Bahadur

Season 16 - Episode 104

Looters queue up in the U.K., Europe needs a war to cling to, and Jay Bahadur gets the pirates of Somalia talking.

John Coffee

Season 16 - Episode 105

Wisconsin's populist-off comes to a head, Larry Wilmore wants Barack Obama to go blacker, and John Coffee pins down credit rating agencies.

Michael Wallis

Season 16 - Episode 106

The Best F#@king News Team covers the Iowa straw poll, Megyn Kelly comes back fighting, and Michael Wallis reveals the real David Crockett.

Ali Velshi

Season 16 - Episode 107

Michele Bachmann wins the Iowa straw poll, Rick Perry announces his presidential candidacy, and Ali Velshi knows how to speak money.

Matt Long

Season 16 - Episode 108

The media loves Michele Bachmann, Rick Perry hits on America, John Hodgman rethinks bookstores, and veteran firefighter Matt Long survived b...

Michael Steele

Season 16 - Episode 109

The media shifts its focus to Paul Ryan, John Oliver and Wyatt Cenac explore racial language in politics, and Michael Steele discusses the f...

Anne Hathaway

Season 16 - Episode 110

Warren Buffett enters the "class warfare" fray, Fitch downgrades New Jersey's credit rating, and Anne Hathaway talks Scrabble strategy.

Buddy Roemer

Season 16 - Episode 111

The media scrutinizes Barack Obama's speech scheduling, James Hoffa Jr. upsets conservatives, and Buddy Roemer discusses his presidential ca...

Dr. Sanjay Gupta

Season 16 - Episode 112

Mitt Romney and Rick Perry battle it out, the U.S. Postal Service faces bankruptcy, and Dr. Sanjay Gupta explores the terrifying effects of ...

Marion Cotillard

Season 16 - Episode 113

GOP candidates square off at the presidential debate, Rick Perry rickrolls Mitt Romney, and Marion Cotillard discusses her fear of contagion...

Mike Mullen

Season 16 - Episode 114

Barack Obama hits congressional Republicans with his jobs speech, America should settle for a campaign-driven economy, and Admiral Mike Mull...

Jim Lehrer

Season 16 - Episode 115

CNN and the Tea Party team up, Rick Perry gets a beatdown, and Jim Lehrer discusses the tensions of presidential debates.

Common

Season 16 - Episode 116

Dick Cheney's medical equipment humanizes him, the Democrats lose a congressional seat, and Common tries to make sense of it all in his memo...

Caroline Kennedy

Season 16 - Episode 117

Congress investigates the Solyndra scandal, Kristen Schaal unveils her pro-vagina campaign products, and Caroline Kennedy commemorates her p...

Ron Suskind

Season 16 - Episode 118

Jason Jones reports on the end of "don't ask, don't tell"; Wyatt Cenac examines America's loss of UFOs to China; and Ron Suskind evaluates B...

Mitch Daniels

Season 16 - Episode 119

Barack Obama presents his tax plan, the super rich risk extinction, and Mitch Daniels discusses the American economy.

Jennifer Granholm

Season 16 - Episode 120

John Oliver and Aasif Mandvi fight over sacred ground, Lewis Black evaluates the threats American kids face, and Jennifer Granholm discusses...

Ron Paul

Season 16 - Episode 121

Rick Santorum thinks sex is a non-issue, the GOP calls for Chris Christie to run for president, and Ron Paul delivers his political message.

Seth Rogen

Season 16 - Episode 122

Barack Obama gets heckled in Hollywood, Larry Wilmore discusses the black vote, and Seth Rogen explores the lighter side of cancer.

Bill O'Reilly

Season 16 - Episode 123

Pundits interpret Chris Christie's message, Sarah Palin weighs the presidential pros and cons, and Bill O'Reilly talks job creator taxes.

Tony Bennett

Season 16 - Episode 124

An NYPD officer pepper-sprays protestors, the NRA unveils a conspiracy theory, and Tony Bennett collaborates with young artists on "Duets II...